This anthology draws bold comparisons between secularist strategies to contain, privatize, and discipline religion and the treatment of racialized subjects by the American state. Specializing in history, literature, anthropology, theology, religious studies, and political theory, contributors expose secularism's prohibitive practices in all facets of American society and suggest opportunities for change.

The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

In the modern moral luck debate, Kant is standardly taken to be the enemy of moral luck. My goal in this paper is to show that this is mistaken. The paper is divided into six sections. In the first, I show that participants in the moral luck literature take moral luck to be anathema to Kantian ethics. In the second, I explain the kind of luck I am going to focus on here: consequence luck, a species of resultant luck. In (...) the third, I explain why philosophers have taken Kantian ethics to reject moral luck and, in particular, consequence luck. In the fourth, I explain why these philosophers are mistaken, and I set out Kant’s theoretical framework for consequence luck. In the fifth, I clarify and defend this framework, and in the sixth, I interrogate and attack it. (shrink)

This book proposes a new paradigm for the interpretation of Plato's early and middle dialogues. Rejecting the usual assumption of a distinct 'Socratic' period in the development of Plato's thought, this view regards the earlier works as deliberate preparation for the exposition of Plato's mature philosophy. Differences between the dialogues do not represent different stages in Plato's own thinking but rather different aspects and moments in the presentation of a new and unfamiliar view of reality. Once the fictional character of (...) the Socratic genre is recognised, there is no reason to regard Plato's early dialogues as representing the philosophy of the historical Socrates. The result is a unified interpretation of all of the dialogues down to the Republic and the Phaedrus. (shrink)

Since the turn of the millennium, theologians and secular scholars of religion have increasingly begun exploring the relationship between transhumanism and religion. However, analyses of anti-transhumanist apocalypticisms are still rare, and those that exist are situated mainly among broader explorations of religious and secular bioconservatism. This article addresses this lack of specificity by drawing analyses of transhumanism and religion into dialogue with explorations of contemporary demonology through a close study of the beliefs of the evangelical conspiracist Thomas Horn and the (...) anti-transhumanist milieu around him. Exploring the milieu's multifaceted demonology of the secular world in light of genealogies of religion and secularity, the article situates Horn's demonology as one attempt to negotiate these genealogies, using what Sean McCloud terms a “‘supernatural’ hermeneutics of suspicion” that sees spiritual forces as the structural base of reality. It argues that, while fringe, milieus like Horn's illuminate broader cultural tensions and genealogical relations surrounding the place of religion in a secular world. (shrink)

ABSTRACTAwe is described as an a “epistemic emotion” because it is hypothesised to make gaps in one’s knowledge salient. However, no empirical evidence for this yet exists. Awe is also hypothesised...

In light of the myriad accounting and corporate ethics scandals of the early 21st century, many corporate leaders and management scholars believe that ethics education is an essential component in business school education. Despite a voluminous body of ethics education literature, few studies have found support for the effectiveness of changing an individual's ethical standards through programmatic ethics training. To address this gap in the ethics education literature the present study examines the influence of an underlying social cognitive error, called (...) pluralistic ignorance. We believe that if pluralistic ignorance is reduced, the result will be more effective business ethics education programs. Eighty undergraduate management students participated in this longitudinal study, and a mixed-model ANOVA revealed that the reduction of pluralistic ignorance resulted in higher personal ethical standards over the course of a semester, when compared to a class that did not receive a formal ethics education program as part of their course. We discuss the implications of pluralistic ignorance in training business ethics and ethics education. (shrink)

In this commentary we argue that evolution of the human brain to host the language system was accomplished by the selective development of frontal and temporal areas in the left hemisphere. The unilateral development of Broca's and Wernicke's areas could have resulted from one or more transcription factors that have an expression pattern restricted to the left hemisphere.

(No abstract is available for this citation).

In this article, I explicate Kant’s position on the wide right to abortion. That is, I explore the extent to which, according to Kant’s practical philosophy, abortion is punishable, even if it involves an unjust infringement of the right to life. By focusing on the state’s right to punish, rather than the right to life or the onset of personhood, I use Kant to expose a novel range of issues and questions about the legal status of abortion (and criminal punishment (...) more generally). The article is divided into four sections. In the first, I lay the groundwork for Kant’s theory of rights and briefly canvass some of the literature on Kantian approaches to abortion. In the second, I look at Kant’s discussion of equivocal rights. In the third, I turn to Kant’s discussions of capital punishment and suicide. In the fourth, I examine Kant on honor killings, and I use his position on infanticide in order to extrapolate and explain his ideas about the right to punish in the context of abortion. (shrink)

Charles Taylor’s A Secular Age generated a great deal of attention—and has stimulated important debates—among a diverse range of scholars in sociology, history, politics, religious studies and to a lesser extent, anthropologists. Much of the debate has focused on the implications of Taylor’s work for the so-called secularisation thesis and the place of religion in the so-called public sphere. The essays in this volume arise less out of such concerns and more from Taylor’s discussion of secularism in a third, ‘experiential’ (...) sense. Each paper addresses the question of what it is like to ‘believe’ in the modern world. Among other things the authors of the essays published in this Special Issue are concerned to develop better understandings of the conditions under which belief and unbelief may be experienced as open, rather than closed, to the possibility of other ontological construals, thereby building on Taylor’s insights into the phenomenology of modern secularism. (shrink)

We argue that the pivotal role assigned by Northoff to the principle of top-down modulation in catatonia might successfully be applied to other symptoms of schizophrenia, for example, hallucinations. Second, we propose that Northoff's account would benefit from a more comprehensive analysis of the cognitive level of explanation. Finally, contrary to Northoff, we hypothesize that “top-down modulation” might play as important a role as “horizontal modulation” in affective-behavioral alterations.

Burns proposes an intriguing hypothesis by suggesting that the “schizophrenia genes” might not be regulatory genes themselves, but rather closely associated with regulatory genes directly involved in the proper growth of the social brain. We point out that this account would benefit from incorporating the effects of localized lesions and aberrant hemispheric asymmetry on cortical connectivity underlying the social brain. In addition, we argue that the evolutionary framework is superfluous.

Using his two-dimensional semantics, I demonstrate that David Chalmers’s 2010 ‘two-dimensional argument against materialism’ is sound only if a wide swath of reductive physicalist theses – crucially, those involving identity and other intrinsic reductive relations – are inconceivable. 2DA therefore begs the question against its opponents and undermines its argumentative relevance. Comparisons are drawn to similar arguments in Marton and Sturgeon; the present account differs in its formal and philosophical simplicity, as well as its specific application to reductivist doctrines beyond (...) the ineffective and merely supervenient. (shrink)

In this anthropological investigation of the nature of an underdeveloped peasant economy, Joel S. Kahn attempts to develop the insights generated by Marxist theorists, by means of a concrete case study of a peasant village in the Indonesian province of West Sumatra. He accounts for the specific features of this regional economy, and, at the same time, examines the implications for it of the centuries-old European domination of Indonesia. The most striking feature of the Minangkabau economy is the predominance (...) of petty commodity relations in agriculture, handicrafts and the local network of distribution. Dr Kahn illustrates this with material on local economic organization, which he collected in the field in the highland village of Sungai Puar, the site of a blacksmithing industry, and with published and unpublished data from other parts of Indonesia. Dr Kahn's book is unusual for its combination of a theoretical analysis of underdevelopment with a detailed regional study. It will appeal to those interested in South-east Asian studies, in development, and in neo-Marxist approaches in anthropology. (shrink)

BackgroundEthics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this governance mechanism is still fit for purpose in the data-driven research context remains a debated issue among research ethics experts.Main textIn this article, we seek to address this issue in a twofold manner. First, we review the strengths and weaknesses of ERCs in ensuring ethical oversight. Second, we map (...) these strengths and weaknesses onto specific challenges raised by big data research. We distinguish two categories of potential weakness. The first category concerns persistent weaknesses, i.e., those which are not specific to big data research, but may be exacerbated by it. The second category concerns novel weaknesses, i.e., those which are created by and inherent to big data projects. Within this second category, we further distinguish between purview weaknesses related to the ERC’s scope (e.g., how big data projects may evade ERC review) and functional weaknesses, related to the ERC’s way of operating. Based on this analysis, we propose reforms aimed at improving the oversight capacity of ERCs in the era of big data science.ConclusionsWe believe the oversight mechanism could benefit from these reforms because they will help to overcome data-intensive research challenges and consequently benefit research at large. (shrink)

Probably the most influential critique of social theorizing about the non-West in recent years has been one emanating from a `subalternist' perspective, by which I mean a critique mounted if not by, then in the name of, peoples/cultures/modes of thought that have been dominated culturally by `the West'. The rapid rise to prominence - economic, political, strategic and cultural - of an increasingly large number of nation states in the Asia-Pacific region poses a rather different kind of challenge to western (...) perspectives on the project of modernity, a challenge to which social theory has yet to formulate an adequate response. Focusing on Malaysia, this paper examines the claims advanced by certain members of the new Asian political elite and intellectuals that Asian countries have discovered divergent trajectories of modernization, and argues that attempts on the part of contemporary western observers to dismiss these claims have so far been unconvincing. This suggests that social theorists need in future to give more serious consideration to the possibility that the `rise of Asia' represents a new kind of modernization. (shrink)

This article provides some reflections on the problem posed by ostensibly perverse phenomena like political patronage, corruption and crony capitalism for modernising narratives, which are currently enjoying a renewed popularity. In the light of an ethnographic example from Indonesia, it is argued that the continual attempt to relocate such phenomena to terrains not properly modern precludes the possibility of serious analysis or moral/political assessment of these phenomena. The starting point for any genuine engagement with these issues is the recognition that (...) these phenomena are as internal to modernity as the modernist discourses that seek to externalise them. (shrink)

This paper develops an approach to the scientific realism debate that has three main features. First, our approach admits multiple criteria of reality, i.e., criteria that, if satisfied, warrant belief in the reality of hypothetical entities. Second, our approach is experiment-based in the sense that it focuses on criteria that are satisfied by experiments as opposed to theories. Third, our approach is local in the sense that it focuses on the reality of particular kinds of entities. We apply this approach (...) to a case that many philosophers have debated, namely, Jean Perrin’s work on atoms and molecules. We provide a novel account by arguing that Perrin’s work warranted a minimal belief in the reality of atoms and molecules as unobservable, discrete particles by satisfying a criterion of reality that we call experimental determination of number per unit. By doing so, he confirmed Avogadro’s hypothesis, but he did not confirm other key constituents of the atomic theories involved. We argue that our account of Perrin’s work is preferable to several other accounts, and we use this as a reason in support of our approach to the realism debate more generally. (shrink)

Using Fredric Jameson’s theory of the ideologeme to trace representations of working- and white working-class characters through a selection of contemporary literary texts, this article shows how t...

This piece argues that free migration was a central if implicit part of the liberal social contract and that America’s founders were both aware of this and exploited it to legitimate their new state. The piece begins by describing this uniquely American contribution to liberal political thought. It then juxtaposes this contribution against the nature of our own international order, to show just how foreign the American Century has become. The piece closes with a short depiction of what an American (...) Century would look like today—were it true to this early ideal—and comments on its feasibility. (shrink)

While some studies suggest cultural differences in visual processing, others do not, possibly because the complexity of their tasks draws upon high-level factors that could obscure such effects. To control for this, we examined cultural differences in visual search for geometric figures, a relatively simple task for which the underlying mechanisms are reasonably well known. We replicated earlier results showing that North Americans had a reliable search asymmetry for line length: Search for long among short lines was faster than vice (...) versa. In contrast, Japanese participants showed no asymmetry. This difference did not appear to be affected by stimulus density. Other kinds of stimuli resulted in other patterns of asymmetry differences, suggesting that these are not due to factors such as analytic/holistic processing but are based instead on the target-detection process. In particular, our results indicate that at least some cultural differences reflect different ways of processing early-level features, possibly in response to environmental factors. (shrink)

This chapter examines the work in chemistry that led to the discovery of boron and explores the implications of this episode for the scientific realism debate. This episode begins with Lavoisier’s oxygen theory of acidity and his prediction that boracic acid contains oxygen and a hypothetical, combustible substance that he called the boracic radical. And it culminates in the work of Davy, Gay-Lussac, and Thénard, who used potassium to extract oxygen from boracic acid and thereby discovered boron. This episode constitutes (...) a novel predictive success of Lavoisier’s theory of acidity, which was not even approximately true. Selective realists attempt to accommodate such false-but-successful theories by showing that their success is due to the fact that they have approximately true parts. This episode poses a strong challenge to selective realism because the parts of Lavoisier’s theory that are responsible for its success are not even approximately true. (shrink)

No consensus yet exists on how to handle incidental fnd-ings in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are fndings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers (...) have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

While the bioethics literature demonstrates that the field has spent substantial time and thought over the last four decades on the goals, methods, and desired outcomes for service and training in bioethics, there has been less progress defining the nature and goals of bioethics research and scholarship. This gap makes it difficult both to describe the breadth and depth of these areas of bioethics and, importantly, to gauge their success. However, the gap also presents us with an opportunity to define (...) this scope of work for ourselves and to help shape the broader conversation about the impact of academic research. Because of growing constraints on academic funding, researchers and scholars in many fields are being asked to demonstrate and also forecast the value and impact of their work. To do that, and also to satisfy ourselves that our work has meaningful effect, we must understand how our work can motivate change and how that change can be meaningfully measured. In a field as diverse as bioethics, the pathways to and metrics of change will likewise be diverse. It is therefore critical that any assessment of the impact of bioethics research and scholarship be informed by an understanding of the nature of the work, its goals, and how those goals can and ought to be furthered. In this paper, we propose a conceptual model that connects individual bioethics projects to the broader goals of scholarship, describing the translation of research and scholarly output into changes in thinking, practice, and policy. One of the key implications of the model is that impact in bioethics is generally the result of a collection of projects rather than of any single piece of research or scholarship. Our goal is to lay the groundwork for a thoroughgoing conversation about bioethics research and scholarship that will advance and shape the important conversation about their impact. (shrink)

We aim to develop a form of debunking argument according to which an agent’s belief is undermined if the reasons she gives in support of her belief are best explained as rationalizations. This approach is a more sophisticated form of what Shaun Nichols has called best-explanation debunking, which he contrasts with process debunking, i.e., debunking by means of showing that a belief has been generated by an epistemically defective process. In order to develop our approach, we identify an example of (...) such a best-explanation debunking argument in Joshua Greene’s attack on deontology. After showing that this argument is not an instance of process debunking, we offer our best-explanation approach as a generalization of Greene’s argument. Finally, we defend our approach by showing that it is not susceptible to some criticisms that Nichols has leveled against a less sophisticated form of best-explanation debunking. (shrink)

Background: In prior reports, we described the design and initial performance of a fully implantable, bi-directional neural interface system for use in deep brain and other neurostimulation applications. Here we provide an update on the chronic, long-term neural sensing performance of the system using traditional 4-contact leads and extend those results to include directional 8-contact leads.Methods: Seven ovine subjects were implanted with deep brain stimulation leads at different nodes within the Circuit of Papez: four with unilateral leads in the anterior (...) nucleus of the thalamus and hippocampus; two with bilateral fornix leads, and one with bilateral hippocampal leads. The leads were connected to either an Activa PC+S® or Percept PC°ledR deep brain stimulation and recording device. Spontaneous local field potentials, evoked potentials, LFP response to stimulation, and electrode impedances were monitored chronically for periods of up to five years in these subjects.Results: The morphology, amplitude, and latencies of chronic hippocampal EPs evoked by thalamic stimulation remained stable over the duration of the study. Similarly, LFPs showed consistent spectral peaks with expected variation in absolute magnitude dependent upon behavioral state and other factors, but no systematic degradation of signal quality over time. Electrode impedances remained within expected ranges with little variation following an initial stabilization period. Coupled neural activity between the two nodes within the Papez circuit could be observed in synchronized recordings up to 5 years post-implant. The magnitude of passive LFP power recorded from directional electrode segments was indicative of the contacts that produced the greatest stimulation-induced changes in LFP power within the Papez network.Conclusion: The implanted device performed as designed, providing the ability to chronically stimulate and record neural activity within this network for up to 5 years of follow-up. (shrink)

People recognize faces of their own race more accurately than faces of other races. The “contact” hypothesis suggests that this “other‐race effect” occurs as a result of the greater experience we have with own‐ versus other‐race faces. The computational mechanisms that may underlie different versions of the contact hypothesis were explored in this study. We replicated the other‐race effect with human participants and evaluated four classes of computational face recognition algorithms for the presence of an other‐race effect. Consistent with the (...) predictions of a developmental contact hypothesis, “experience‐based models” demonstrated an other‐race effect only when the representational system was developed through experience that warped the perceptual space in a way that was sensitive to the overall structure of the model's experience with faces of different races. When the model's representation relied on a feature set optimized to encode the information in the learned faces, experience‐based algorithms recognized minority‐race faces more accurately than majority‐race faces. The results suggest a developmental learning process that warps the perceptual space to enhance the encoding of distinctions relevant for own‐race faces. This feature space limits the quality of face representations for other‐race faces. (shrink)

I argue that it was rational for chemists to eliminate phlogiston, but that it also would have been rational for them to retain it. I do so on the grounds that a number of prominent phlogiston theorists identified phlogiston with hydrogen in the late 18th century, and this identification became fairly well entrenched by the early 19th century. In light of this identification, I critically evaluate Hasok Chang’s argument that chemists should have retained phlogiston, and that doing so would have (...) benefited science. I argue that these benefits would have been unlikely, and I go on to consider some more likely benefits and harms of retaining phlogiston. I conclude that there is a sense in which scientific rationality concerns what is permissible, as opposed to what is required, so that retention and elimination may, at least sometimes, both be rationally permissible options. (shrink)

This paper argues against a particular version of the inference from the success of a scientific theory to the claim that the theory must be approximately true to some extent. The kind of success at issue is comparative, where one theory is more empirically successful than its rival if that theory predicts phenomena that are inexplicable or anomalous according to its rival. A theory that exhibits this kind of comparative success can be seen as thereby achieving empirical progress over its (...) rival. David Harker has developed a form of selective scientific realism based on the idea that this kind of success is evidence for the approximate truth of the parts of theories responsible for such success. Counterexamples to Harker’s position are cases in which a theory is more successful than its rival in virtue of containing parts that are not even approximately true. In order to identify some counterexamples to Harker’s position, this paper considers four historical cases that Greg Frost-Arnold has recently used to motivate a novel historical challenge to realism called the Problem of Misleading Evidence. This paper argues that these four cases are counterexamples to Harker’s position, and that they provide a strong reason to doubt his position and the kind of success-to-truth inference that he defends. (shrink)

A number of prominent defenders of the phlogiston theory identified phlogiston with hydrogen in the late eighteenth century, and I argue that this identification was fairly well-entrenched by the early nineteenth century. In light of this identification, I examine the ways in which retaining phlogiston could have retarded scientific progress, and also the ways in which it could have benefited science. I argue that it was rational for chemists to eliminate phlogiston, but that it also would have been rational for (...) them to retain it. I situate my arguments for these claims in relation to Hasok Chang's recent work on the Chemical Revolution. And I conclude that there is a sense in which scientific rationality concerns what is permissible, as opposed to what is required, so that retention and elimination may, at least sometimes, both be rationally permissible options. (shrink)

This paper aims to defend the use of the notion of experimental individuation, which has recently been developed by Ruey-Lin Chen, as a criterion for the reality of theoretical entities. In short, when scientists experimentally individuate an entity, a realist conclusion about that entity is warranted. We embed this claim regarding experimental individuation within a framework that allows for other criteria of reality. And we understand so-called retail arguments regarding the reality of a particular theoretical entity as arguments that concern (...) choosing an appropriate criterion of reality for that entity and determining whether the relevant first-order scientific evidence satisfies that criterion. We argue that such retail arguments are philosophical because defending criteria of reality, and showing that they are or are not satisfied in particular cases, involves work that is distinctively philosophical. And we illustrate this philosophical work by applying our criterion of experimental individuation to three historical cases: Davy’s potassium, Lavoisier’s muriatic radical, and Thomson’s electrified particles. (shrink)

Medical-legal partnerships connect legal advocates to healthcare providers and settings. Maintaining effectiveness of medical-legal partnerships and consistently identifying opportunities for innovation and adaptation takes intentionality and effort. In this paper, we discuss ways in which our use of data and quality improvement methods have facilitated advocacy at both patient (client) and population levels as we collectively pursue better, more equitable outcomes.